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Bacillus subtilis has a profound effect when used as a probiotic feed additive in aquaculture. This is because it not only improves gut health of aquatic animals, but it also has the ability to clean the pond that the animals are farmed in, as well as purifying the water of the environment they live in.

Bacillus subtilis plays a critical role in improving gut health of humans and animals alike. It can reach all of the large and small intestines, and this crowds out harmful bacteria to prevent disease, which raises overall immunity.

Bacillus subtilis is widely used not only in feed, but also in sewage treatment and biofertilizer fermentation or fermentation bed production. It is a multifunctional microorganism.

When it comes to Bacillus subtilis, there are many mechanisms of action to be discussed. Bacillus subtilis is a very popular bacteria because of its many applications and benefits not only to humans, but to animals and plants as well.

Bacillus subtilis is a widely known probiotic that has various fields of application. It was universally recognized as the most beneficial bacteria of 2023. In this series, the various fields, and mechanisms, and advantages of Bacillus subtilis will be shown.

In previous studies, a variety of effective antibacterial substances were isolated and purified from Bacillus amyloliquefaciens, and its application in pig industry is reviewed in order to provide reference for development of the application of Bacillus amyloliquefaciens as a safe and green probiotic.

In recent years, domestic and foreign research has found that the antibacterial mechanism of Bacillus amyloliquefaciens mainly includes the production of antagonistic and lytic effects.

​It has been confirmed that Bacillus amyloliquefaciens can produce polyketide compounds and explored its possible mechanism. Furthermore, Lipopeptide substances are one of the main antibacterial substances produced by Bacillus amyloliquefaciens.

The advantages of microbial agents in aquaculture are increasingly recognized. However, some conditionally pathogenic Bacillus species can cause diseases such as skin rot and sepsis in aquatic animals, and their safe use has become an issue that cannot be ignored in the aquaculture water environment.